30752-31-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-4-(cyclohexyloxy)benzene serves as an intermediate in the production of pharmaceuticals, playing a crucial role in the synthesis of various medicinal compounds due to its unique chemical structure.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1-Bromo-4-(cyclohexyloxy)benzene is utilized as an intermediate, contributing to the development of agricultural chemicals that can enhance crop protection and productivity.
Used as a Building Block in Organic Synthesis:
Beyond its applications in pharmaceuticals and agrochemicals, 1-Bromo-4-(cyclohexyloxy)benzene also functions as a building block in the synthesis of a range of other organic compounds, broadening its utility in the field of organic chemistry.
Safety Considerations:
Given its classification as a hazardous chemical, 1-Bromo-4-(cyclohexyloxy)benzene can cause irritation to the skin, eyes, and respiratory system. Therefore, it is imperative to adopt proper safety measures and use personal protective equipment when handling 1-bromo-4-(cyclohexyloxy)benzene to minimize health risks.

Upstream product

• 106-41-2 4-bromo-phenol 
• 110-83-8 cyclohexene 
• 2206-38-4 cyclohexylphenyl ether 
• 589-87-7 1,4-bromoiodobenzene 
• 108-93-0 cyclohexanol 
• 98-89-5 Cyclohexanecarboxylic acid 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 

Downstream Products

• 59446-96-7 p-(Phenoxyphenoxy)cyclohexan 
• 189117-08-6 (E,E)-1-(4-hydroxyphenyl)-4-(4-tolyl)-1,2,3,4-tetrafluoro-1,3-butadiene 
• 189116-97-0 (E,E)-1-[4-(cyclohexyloxy)phenyl]-4-(4-tolyl)-1,2,3,4-tetrafluoro-1,3-butadiene 
• 570398-88-8 (4-(cyclohexyloxy)phenyl)boronic acid 
• 2206-38-4 cyclohexylphenyl ether 
• 1331776-62-5 1-cyclobutyl-2-(4-cyclohexyloxyphenyl)ethanone 
• 1331776-66-9 4-[6-cyclobutyl-5-(4-cyclohexyloxyphenyl)pyridazin-3-yloxy]piperidine-1-carboxylic acid tert-butyl ester 
• 1331776-65-8 6-chloro-3-cyclobutyl-4-(4-cyclohexyloxyphenyl)pyridazine 
• 1331776-64-7 6-cyclobutyl-5-(4-cyclohexyloxyphenyl)-2H-pyridazin-3-one 
• 1331776-63-6 4-cyclobutyl-3-(4-cyclohexyloxyphenyl)-2-hydroxy-4-oxobutyric acid ethyl ester 

Relevant academic research and scientific papers

MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidases SpsB and/or LepB, an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

THERAPEUTIC COMPOUNDS

The present disclosure relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R3 have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

Decarboxylative C(sp3)?O Cross-Coupling

Alkyl aryl ethers are an important class of compounds in medicinal and agricultural chemistry. Catalytic C(sp3)?O cross-coupling of alkyl electrophiles with phenols is an unexplored disconnection strategy to the synthesis of alkyl aryl ethers, with the potential to overcome some of the major limitations of existing methods such as C(sp2)?O cross-coupling and SN2 reactions. Reported here is a tandem photoredox and copper catalysis to achieve decarboxylative C(sp3)?O coupling of alkyl N-hydroxyphthalimide (NHPI) esters with phenols under mild reaction conditions. This method was used to synthesize a diverse set of alkyl aryl ethers using readily available alkyl carboxylic acids, including many natural products and drug molecules. Complementarity in scope and functional-group tolerance to existing methods was demonstrated.

SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK AND THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASE

Compounds of Formula I, as shown below and defined herein: and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and methods of treating diseases including cancer, inflammation, and autoimmune disease mediated at least in part by Bruton's Tyrosine Kinase (BTK).

PHENYL-HETEROARYL DERIVATIVES AND METHODS OF USE THEREOF

The present invention provides phenyl-heteroaryl derivatives of Formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of RAGE-mediated diseases such as Alzheimer's Disease. The present invention further relates to methods for the preparation of compounds of Formula (I) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the use of such compounds and/or pharmaceutical compositions in treating RAGE-mediated diseases.

Base catalyzed Mitsunobu reactions as a tool for the synthesis of aryl sec-alkyl ethers

A facile and versatile method for the synthesis of aryl sec-alkyl ethers from phenols with alcohols in the presence of base via a Mitsunobu reaction is described.

Copper-catalyzed etherification of aryl iodides using KF/Al 2O3: An improved protocol

A simple and efficient method for the coupling of aryl iodides with aliphatic alcohols and phenols that does not require the use of alkoxide bases is described. This C-O bond forming procedure shows that the combination of air stable CuI and 1,10-phenanthroline in the presence of KF/Al2O 3 comprises an extremely efficient and general catalyst system for the etherification of aryl iodides. Different functionalized aryl iodides were coupled with alcohols and phenols using this method.

Kaolin-assisted Aromatic Chlorination and Bromination

Moist kaolin catalyses the regioselective and high-yielding chlorination and bromination of C6H5OR (R = C1-C8 alkyl. Bu1, allyl, cyclohexyl, benzyl) to 4-XC6H4OR (X = Cl and Br, respectively) with NaCl02 and Mn(acac)3 in CH2Cl2 in the absence and presence of NaBr, respectively, under mild and neutral conditions.