tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate

Base Information

• Chemical Name: tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate
• CAS No.: 1616288-91-5
• Molecular Formula: C₂₂H₃₀N₂O₄
• Molecular Weight: 386.491
• Mol file: 1616288-91-5.mol

Synonyms:tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate

Chemical Property of tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate

There total 6 articles about tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethanol (1616288-89-1) → tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate (1616288-91-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

2-hydroxy-4,6-dimethyl-3-carbonitrile (769-28-8,70254-47-6) → tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate (1616288-91-5)

Guidance literature:

Multi-step reaction with 5 steps

1: silver(l) oxide / toluene / 20 h / 110 °C

2: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3: methanol / 1 h / 20 °C

4: methanol; sodium cyanoborohydride / 0 - 20 °C

5: triethylamine / dichloromethane / 18 h / 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; silver(l) oxide; In methanol; dichloromethane; toluene;

Reference yield:

2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile (53475-53-9) → tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate (1616288-91-5)

Guidance literature:

Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

2: methanol / 1 h / 20 °C

3: methanol; sodium cyanoborohydride / 0 - 20 °C

4: triethylamine / dichloromethane / 18 h / 20 °C

With methanol; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; In methanol; dichloromethane; toluene;

upstream raw materials:

2-hydroxy-4,6-dimethyl-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile

2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

di-tert-butyl dicarbonate

Downstream raw materials:

ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

4-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-9-bromo-7-isopropoxy-6-methyl-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

4-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-6-methyl-9-[2-(methylamino)pyrimidin-5-yl]-7-(propan-2-yloxy)-3,4-dihydro-1,4-benzoxazepin-5(2H)-one