1-Methoxy-1-trimethylsilyloxypropene

Base Information

• Chemical Name: 1-Methoxy-1-trimethylsilyloxypropene
• CAS No.: 34880-70-1
• Molecular Formula: C7H16 O2 Si
• Molecular Weight: 160.288
• Hs Code.: 2931900090
• European Community (EC) Number: 672-695-4
• Nikkaji Number: J355.670K,J428.863G
• Wikidata: Q76416046
• Mol file: 34880-70-1.mol

Synonyms:1-Methoxy-1-trimethylsilyloxypropene;34880-70-1;[(1-Methoxy-1-propenyl)oxy]trimethylsilane;[(E)-1-methoxyprop-1-enoxy]-trimethylsilane;(E)-(1-methoxyprop-1-enyloxy)trimethylsilane;RTHAKVSHSCPUGI-VOTSOKGWSA-N;MFCD00671554;AKOS006229015;1-Methoxy-1-(trimethylsilyloxy)propene;FS-5881;72658-09-4;(E)-1-Methoxy-1-trimethylsiloxy-1-propene;1-Methoxy-1-(trimethylsilyloxy)prop-1-ene;O-Methyl-O-trimethylsilylmethylketene acetal;M1199;[(e)-1-methoxyprop-1-enyloxy]trimethylsilane;T72343;[(e)-1-methoxy-1-propenyl]oxy(trimethyl)silane

Chemical Property of 1-Methoxy-1-trimethylsilyloxypropene

Chemical Property:

• Vapor Pressure: 9.805mmHg at 25°C
• Refractive Index: 1.415
• Boiling Point: 52 °C / 27mmHg
• Flash Point: 23.505°C
• PSA: 18.46000
• Density: 0.87
• LogP: 2.34560
• Storage Temp.: 0-10°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 160.091956283
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methoxy-1-trimethylsilyloxypropene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC=C(OC)O[Si](C)(C)C
• Isomeric SMILES: C/C=C(\OC)/O[Si](C)(C)C

Technology Process of 1-Methoxy-1-trimethylsilyloxypropene

There total 1 articles about 1-Methoxy-1-trimethylsilyloxypropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

chloro-trimethyl-silane (75-77-4) + propanoic acid methyl ester (554-12-1) → [1-methoxyprop-1-enyloxy]trimethylsilane (34880-70-1)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 3.5h;

Reference yield: 100.0%

[1-methoxyprop-1-enyloxy]trimethylsilane (34880-70-1) + 2,3,5,6-tetramethyl-4-oxo-1-phenylthiocyclohexa-2,5-dienyl 2-chloroacetate (194720-38-2) → methyl 2-(phenylthio)propanoate (21673-18-7)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at -30 - 20 ℃; for 0.166667h;

DOI:10.1021/jo001710q

Reference yield: 99.0%

benzophenone (119-61-9) + [1-methoxyprop-1-enyloxy]trimethylsilane (34880-70-1) → methyl 2-methyl-3,3-diphenyl-3-(trimethylsilyloxy)propanoate

Guidance literature:

With C₆H₅O^(1-)*C₁₃H₂₇KO₆⁽¹⁺⁾; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tetlet.2009.01.028

upstream raw materials:

chloro-trimethyl-silane

propanoic acid methyl ester

Downstream raw materials:

methyl pyruvate oxime

methyl 2-(2-cyclohexanone)-propionate

methyl 2-(3-trimethylsiloxycyclohex-2-enyl)propionate

3,1'-syn-3-<1'-(carbomethoxy)ethyl>-1-<(trimethylsilyl)oxy>-1-cyclohexene

Refernces

• 1、 Chan, Jessica Z.,Chang, Yejin,Wasa, Masayuki. "B(C6F5)3-Catalyzed C-H Alkylation of N-Alkylamines Using Silicon Enolates without External Oxidant". supporting information. p. 984 - 988. Retrieved 2019/02/14.
• 2、 Oisaki, Kounosuke,Zhao, Dongbo,Kanai, Motomu,Shibasaki, Masakatsu. "Catalytic enantioselective aldol reaction to ketones". . p. 7164 - 7165. Retrieved 2007/10/03.