2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

Base Information

Chemical Name:2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine
CAS No.:1332875-44-1
Molecular Formula:C₂₉H₃₇ClF₃N₅O₂Si
Molecular Weight:608.179
Hs Code.:

2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

Synonyms:2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

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Chemical Property of 2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

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Technology Process of 2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

There total 9 articles about 2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332875-43-0
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid [2-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-4-yl]-amide

: 1332875-44-1
2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

Guidance literature:: With iron; acetic acid; In ethanol; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-44-1
2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuryl dichloride / dichloromethane / 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 4 h / 20 °C

2.2: pH 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

With sulfuryl dichloride; oxalyl dichloride; water; iron; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;

Reference yield:

: 1245207-40-2
5-tert-butyl-4-chloro-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1332875-44-1
2-(5-tert-Butyl-4-chloro-2-methyl-2H-pyrazol-3-yl)-4-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-6-(2-trifluoromethyl-phenyl)-3H-imidazo[4,5-d]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 4 h / 20 °C

1.2: pH 7

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

3.2: 3 h / Inert atmosphere

4.1: iron / acetic acid / ethanol / 1 h / 100 °C / Inert atmosphere

With oxalyl dichloride; water; iron; sodium hydride; N,N-dimethyl-formamide; sodium hydroxide; acetic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; mineral oil;