N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Base Information

Chemical Name:N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine
CAS No.:1449736-79-1
Molecular Formula:C₂₄H₂₀F₃N₃O
Molecular Weight:423.438
Hs Code.:

N<sup>4</sup>-(4-methoxybenzyl)-N<sup>8</sup>-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Synonyms:N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

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Chemical Property of N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Chemical Property:

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Technology Process of N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

There total 6 articles about N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449737-49-8
8-bromo-N-(4-methoxybenzyl)quinolin-4-amine

: 98-16-8
3-trifluoromethylaniline

: 1449736-79-1
N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Guidance literature:: With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1449737-48-7
8-bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylic acid

: 1449736-79-1
N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: diphenylether / 0.5 h / 240 °C

2: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 100 °C / Microwave irradiation

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In diphenylether; toluene;

Reference yield:

: 206258-97-1
ethyl 4-chloro-8-bromo-3-quinolinecarboxylate

: 1449736-79-1
N⁴-(4-methoxybenzyl)-N⁸-(3-(trifluoromethyl)phenyl)quinoline-4,8-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 120 °C

2: lithium hydroxide; water / tetrahydrofuran; methanol / 12 h / 20 °C

3: diphenylether / 0.5 h / 240 °C

4: tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 0.5 h / 100 °C / Microwave irradiation

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; water; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; lithium hydroxide; sodium t-butanolate; In tetrahydrofuran; methanol; diphenylether; N,N-dimethyl-formamide; toluene;