C₁₈H₁₉N₅O₂

Base Information

Chemical Name:C₁₈H₁₉N₅O₂
CAS No.:1246520-71-7
Molecular Formula:C₁₈H₁₉N₅O₂
Molecular Weight:337.381
Hs Code.:

C<sub>18</sub>H<sub>19</sub>N<sub>5</sub>O<sub>2</sub>

Synonyms:C₁₈H₁₉N₅O₂

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Chemical Property of C₁₈H₁₉N₅O₂

Chemical Property:

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Technology Process of C₁₈H₁₉N₅O₂

There total 12 articles about C₁₈H₁₉N₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246521-44-7
C₁₇H₁₆N₄O₃

: 74-89-5
methylamine

: 1246520-71-7
C₁₈H₁₉N₅O₂

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 17h;

Reference yield:

: 36404-88-3
2-chloro-3-carbaldehydepyridine

: 1246520-71-7
C₁₈H₁₉N₅O₂

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene-4-sulfonic acid; hydrazine hydrate / 21 h / 120 °C / Cooling with ice

2.1: potassium hydroxide; iodine / N,N-dimethyl-formamide / 1 h / 20 °C / Cooling with ice

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

4.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

5.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

5.2: Cooling with ice

6.1: trifluoroacetic acid / 16 h / Reflux

7.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

8.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C

8.2: 7 h / Reflux

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

10.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 17 h / 20 °C

With N-chloro-succinimide; water; hydrogen; iodine; sodium hydride; toluene-4-sulfonic acid; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; HATU; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 117007-52-0
3-iodo-1H-pyrazolo[3,4-b]pyridine

: 1246520-71-7
C₁₈H₁₉N₅O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: triethylamine / triphenylphosphine; palladium diacetate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

3.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: trifluoroacetic acid / 16 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / water; tetrahydrofuran; methanol / 3 h / 20 °C

6.1: N-chloro-succinimide; triphenylphosphine / tetrahydrofuran / 0.03 h / 20 °C

6.2: 7 h / Reflux

7.1: sodium hydroxide; water / tetrahydrofuran; methanol / 4 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU / N,N-dimethyl-formamide; tetrahydrofuran / 17 h / 20 °C

With N-chloro-succinimide; water; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium hydroxide; palladium 10% on activated carbon; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;