N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE

Base Information

• Chemical Name: N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE
• CAS No.: 245765-92-8
• Molecular Formula: C₁₂H₁₇BrN₂O
• Molecular Weight: 285.184
• Hs Code.: 2933399990
• Mol file: 245765-92-8.mol

Synonyms:N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE;5-Bromo-3-methyl-2-(methyl-pivaloylamino)pyridine;5-Bromo-3-methyl-2-(N,2,2,2-tetramethylacetamido)pyridine, 95%

Chemical Property of N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE

Chemical Property:

• Vapor Pressure: 1.16E-05mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 369.7°Cat760mmHg
• PKA: 2.89±0.10(Predicted)
• Flash Point: 177.4°C
• Density: 1.318g/cm³
• Sensitive.: Light Sensitive

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-3-methyl-2-(methyl-pivaloylamino)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE

There total 1 articles about N-(5-BROMO-3-METHYLPYRIDIN-2-YL)-N-METHYL-2,2-DIMETHYLPROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-bromo-6-methylpyridin-2-yl)methylamine (245765-66-6) + pivaloyl chloride (3282-30-2) → N-(5-bromo-3-methyl-2-pyridyl)-N,2,2-trimethylpropanamide (245765-92-8)

Guidance literature:

With pyridine; In toluene; at 100 ℃; for 10.5h;

Reference yield: 93.9%

N-(5-bromo-3-methyl-2-pyridyl)-N,2,2-trimethylpropanamide (245765-92-8) + bis(pinacol)diborane (73183-34-3) → C18H29BN2O3

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium ethanolate; In toluene; at 20 - 80 ℃; for 3h;

upstream raw materials:

(5-bromo-6-methylpyridin-2-yl)methylamine

pivaloyl chloride

Refernces