3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

Base Information

Chemical Name:3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide
CAS No.:1380351-15-4
Molecular Formula:C₃₂H₄₆N₈O₅
Molecular Weight:622.768
Hs Code.:

3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

Synonyms:3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

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Chemical Property of 3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

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Technology Process of 3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

There total 20 articles about 3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21950-36-7
5'-amino-5'-deoxy-2',3'-O-isopropylideneadenosine

: 1380351-15-4
3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / isopropyl alcohol; 1,2-dichloro-ethane / 1 h / 20 °C

1.2: 18 h

2.1: potassium carbonate / acetonitrile / 18 h / 95 °C / Sealed tube

3.1: water; methanol / 0.75 h

3.2: 2 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 42 h

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl (2E)-cyano(hydroxyimino)ethanoate / dichloromethane / 20 °C / Inert atmosphere

With ethyl (2E)-cyano(hydroxyimino)ethanoate; hydrogen; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 1380292-92-1
4-(1-methoxyl-2-methylpropan-2-yl)benzene-1,2-diamine

: 1380351-04-1
3-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(methyl)amino)cyclobutyl)propanoic acid

: 1380351-15-4
3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

Guidance literature:: With ethyl (2E)-cyano(hydroxyimino)ethanoate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 1380351-15-4
3-[3-({[(3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl]methyl}(methyl)amino)cyclobutyl]-N-[2-amino-4-(1-methoxy-2-methylpropan-2-yl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / 1.33 h / 20 °C

2.1: di-isopropyl azodicarboxylate / tetrahydrofuran / 0.25 h / 0 °C

2.2: 18.5 h

3.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 16.5 h / 80 °C

4.1: trimethylphosphane / tetrahydrofuran / 2 h / 0 °C

4.2: 2.75 h / 20 °C

5.1: sodium tris(acetoxy)borohydride; methanol / acetic acid / 2.25 h / 20 °C / Inert atmosphere

6.1: water; sodium cyanoborohydride / acetic acid / methanol / 1 h / 20 °C / pH ~ 6

7.1: sodium hydroxide; water / methanol / 3.5 h / 50 °C

7.2: pH 7

8.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethyl (2E)-cyano(hydroxyimino)ethanoate / dichloromethane / 20 °C / Inert atmosphere

With methanol; di-isopropyl azodicarboxylate; ethyl (2E)-cyano(hydroxyimino)ethanoate; water; sodium tris(acetoxy)borohydride; sodium cyanoborohydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trimethylphosphane; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane; butan-1-ol;