tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate
CAS No.:1383377-64-7
Molecular Formula:C₂₃H₂₄FN₅O₃
Molecular Weight:437.474
Hs Code.:

Synonyms:tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

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Chemical Property of tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

There total 8 articles about tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1383377-50-1
3-fluoro-4-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)-picolinonitrile

: 26690-80-2
2-(N-tert-butoxycarbonylamino)ethanol

: 1383377-64-7
tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -20 - -5 ℃;
DOI:10.1021/jm4006324

Reference yield:

: 863605-34-9
4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1383377-64-7
tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 3 h / 20 - 25 °C

1.2: 10 - 20 °C

1.3: 10 - 25 °C

2.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

3.2: 0.5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; isopropylmagnesium chloride; sodium hydride; caesium carbonate; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1286230-78-1
3-(4-fluorophenyl)-1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

: 1383377-64-7
tert-butyl (2-((2-cyano-4-(3-(4-fluorophenyl)-1-methyl-1Hpyrazol-4-yl)pyridin-3-yl)oxy)ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / N,N-dimethyl-formamide / 20 - 50 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.08 h / 20 °C

2.2: 0.5 h / 20 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;