2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 236406-40-9
• Molecular Formula: C₂₀H₃₀N₂O₂
• Molecular Weight: 330.47
• Hs Code.: 2933990090
• Mol file: 236406-40-9.mol

Synonyms:2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property of 2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 1.47E-07mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 428.9°C at 760 mmHg
• Flash Point: 213.2°C
• PSA: 32.78000
• Density: 1.10
• LogP: 3.78540
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 10 articles about 2-BENZYL-2,8-DIAZA-SPIRO[4.5]DECANE-8-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6) + benzaldehyde (100-52-7) → tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate (236406-40-9)

Guidance literature:

With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; pH=6 - 7;

DOI:10.1021/acsmedchemlett.7b00106

Reference yield:

tert-butyl 2-benzyl-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate (1221818-05-8) → tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate (236406-40-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -20 - 20 ℃; for 2h;

Reference yield:

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester (236406-39-6) + sodium hydrogencarbonate (144-55-8) → tert-butyl 2-benzyl-2,8-diazaspiro[4.5]decane-8-carboxylate (236406-40-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; benzaldehyde; acetic acid; In tetrahydrofuran; water;

upstream raw materials:

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

sodium hydrogencarbonate

C₁₅H₂₉NO₈S₂

benzylamine

Downstream raw materials:

2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

2-benzyl-2,8-diazaspiro[4.5]decane

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