3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

Base Information

Chemical Name:3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide
CAS No.:1427265-30-2
Molecular Formula:C₂₂H₁₉F₂N₅O
Molecular Weight:407.423
Hs Code.:

Synonyms:3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

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Chemical Property of 3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

Chemical Property:

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Technology Process of 3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

There total 3 articles about 3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 7693-46-1
4-Nitrophenyl chloroformate

: 74-89-5
methylamine

: 1427265-30-2
3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

Guidance literature:: 4-fluorobenzoyl chloride; 4-Nitrophenyl chloroformate; With triethylamine; In dichloromethane; at 0 ℃; for 0.75h;

methylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 72h;

Reference yield:

: C₂₇H₁₉F₂N₅O₄

: 74-89-5
methylamine

: 1427265-30-2
3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

Guidance literature:: In tetrahydrofuran; dichloromethane; at 20 ℃; for 72h;

Reference yield:

: 1427265-62-0
3-[1-(2,4-difluorobenzyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]benzonitrile

: 1427265-30-2
3-(3-cyanophenyl)-1-(2,4-difluorobenzyl)-1,4,6,7-tetrahydropyrazolo[4,3-c]pyridine-5-carboxylic acid methylamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.75 h / 0 °C

2: tetrahydrofuran; dichloromethane / 72 h / 20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;