Technology Process of tert-butyl 4-(benzyloxy)-2,6-dimethylbenzoate
There total 2 articles about tert-butyl 4-(benzyloxy)-2,6-dimethylbenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-((4-bromo-3,5-dimethylphenoxy)methyl)benzene;
With
n-butyllithium;
In
N,N-dimethyl-formamide;
at -78 ℃;
for 0.5h;
Inert atmosphere;
di-tert-butyl dicarbonate;
In
N,N-dimethyl-formamide;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
DOI:10.1002/anie.201206370
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / paraffin oil; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / N,N-dimethyl-formamide / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 - 20 °C / Inert atmosphere
With
n-butyllithium; sodium hydride;
In
N,N-dimethyl-formamide; paraffin oil;
DOI:10.1002/anie.201206370
- Guidance literature:
-
With
5%-palladium/activated carbon; hydrogen;
In
methanol;
at 20 ℃;
under 760.051 Torr;
DOI:10.1002/anie.201206370
