4-Fluorobenzenesulfinic acid sodium salt

Base Information

• Chemical Name: 4-Fluorobenzenesulfinic acid sodium salt
• CAS No.: 369-51-7
• Molecular Formula: C6H5 F O2 S
• Molecular Weight: 160.169
• Mol file: 369-51-7.mol

Synonyms:Benzenesulfinicacid, p-fluoro- (8CI); 4-Fluorobenzenesulfinic acid; p-Fluorobenzenesulfinicacid

Chemical Property of 4-Fluorobenzenesulfinic acid sodium salt

Chemical Property:

• PSA: 56.51000
• LogP: 2.27200

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Fluorobenzenesulfinic acid sodium salt

There total 9 articles about 4-Fluorobenzenesulfinic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

4-Fluorobenzenesulfonyl chloride (349-88-2) → 4-fluorobenzenesulfinic acid (369-51-7)

Guidance literature:

With HO^(1-)*H₂Na^(1-); water; sodium sulfite; at 0 - 40 ℃;

DOI:10.1016/j.bmcl.2009.02.036

Reference yield: 57.0%

sodium 4-fluorobenzenesulfinate (824-80-6) → 4-fluorobenzenesulfinic acid (369-51-7)

Guidance literature:

With hydrogenchloride; tert-butyl methyl ether; In water; for 0.5h;

DOI:10.1002/asia.201600761

Reference yield:

4-Fluorothiophenol (371-42-6) → 4-fluorobenzenesulfonic acid (368-88-7) + bis(4-fluorophenyl)disulfide (405-31-2) + 4-fluorobenzenesulfinic acid (369-51-7)

Guidance literature:

With dihydrogen peroxide; In ethanol; Ambient temperature; other p-fluorobenzenethiol, other conditions;

DOI:10.1021/jo00295a020

upstream raw materials:

fluorobenzene

4-Fluorobenzenesulfonyl chloride

4-Fluorothiophenol

4-fluorobenzenesulfinic acid ethyl ester

Downstream raw materials:

3-(p-fluorophenylsulfonyl)-3-methyl-1-propene

2-(4-fluoro-benzenesulfonyl)-benzene-1,4-diol

Refernces

• 1、 Kuang, Kaimo,Wu, Meixia,Wu, Sixin,Xia, Ziqin,Xu, Qiankun,Zhang, Man,Zhou, Nengneng. "tert-Butyl Hydroperoxide-Initiated Radical Cyclization of 1-(Allyloxy)-2-(1-Arylvinyl)Benzenes with Sulfinic Acids to Access Sulfonated Benzoxepines". supporting information. p. 3491 - 3495. Retrieved 2021/06/28.
• 2、 Liu, Qi,Mei, Yousheng,Wang, Lei,Ma, Yongmin,Li, Pinhua. "Visible-Light-Induced Radical Cascade Cyclizations of 1,7-Enynes with Sulfinic Acids: Direct Access to Sulfonated Chromanes and Sulfonated Tetrahydroquinolines under Metal-Free Conditions". supporting information. p. 5669 - 5680. Retrieved 2020/10/28.