3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%
• CAS No.: 1029439-83-5
• Molecular Formula: C₁₂H₁₅BF₂O₃
• Molecular Weight: 256.057
• Mol file: 1029439-83-5.mol

Synonyms:2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Chemical Property of 3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%

Chemical Property:

• Boiling Point: 311.3±42.0 °C(Predicted)
• PKA: 7.15±0.40(Predicted)
• Density: 1.20±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96%

There total 2 articles about 3,5-Difluoro-4-hydroxybenzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

bis(pinacol)diborane (73183-34-3) + 4-bromo-2,6-difluorophenol (104197-13-9) → 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (1029439-83-5)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 3h; Inert atmosphere;

Reference yield:

2,6-difluorophenol (28177-48-2) → 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (1029439-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / Darkness

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 10.5 h / 100 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; potassium acetate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2012.11.054

Reference yield: 70.0%

(+/-)-γ-hydroxy-γ-methylbutyric acid methylester (126252-14-0) + 2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (1029439-83-5) → 4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]pentanoic acid methyl ester

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

upstream raw materials:

bis(pinacol)diborane

4-bromo-2,6-difluorophenol

2,6-difluorophenol

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