3-fluoro-DL-phenylalanine methyl ester hydrochloride

Base Information

• Chemical Name: 3-fluoro-DL-phenylalanine methyl ester hydrochloride
• CAS No.: 64493-16-9
• Molecular Formula: C₁₀H₁₂FNO₂*ClH
• Molecular Weight: 233.67
• Mol file: 64493-16-9.mol

Synonyms:3-fluoro-DL-phenylalanine methyl ester hydrochloride

Chemical Property of 3-fluoro-DL-phenylalanine methyl ester hydrochloride

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

H-M-Fluoro-D-phe-omehcl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-fluoro-DL-phenylalanine methyl ester hydrochloride

There total 5 articles about 3-fluoro-DL-phenylalanine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloro-trimethyl-silane (75-77-4) + L-3-fluorophenylalanine (19883-77-3,2629-54-1) → 3-fluoro-DL-phenylalanine methyl ester hydrochloride (64493-16-9)

Guidance literature:

In methanol;

Reference yield:

methanol (67-56-1) + 3-fluorophenylalanine (456-88-2,2629-54-1) → 3-fluoro-DL-phenylalanine methyl ester hydrochloride (64493-16-9)

Guidance literature:

With thionyl chloride; at 20 ℃; for 48h;

DOI:10.1002/jlcr.918

Reference yield:

2-(3-Fluoro-benzyl)-2-formylamino-malonic acid diethyl ester → 3-fluoro-DL-phenylalanine methyl ester hydrochloride (64493-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 10percent HCl / 4 h / Heating

2: thionyl chloride / 2 h

With hydrogenchloride; thionyl chloride;

DOI:10.1021/jm00157a034

upstream raw materials:

methanol

3-fluoro-DL-phenylalanine ; hydrochloride

3-fluorophenylalanine

m-fluorobenzyl chloride

Downstream raw materials:

(R)-2-amino-3-(3-fluorophenyl)propionic acid

C₁₁H₁₁FNO₆S^(1-)*K⁽¹⁺⁾

3-(3-Fluoro-phenyl)-2-[(imidazole-1-carbonyl)-amino]-propionic acid methyl ester

L-3-fluorophenylalanine

Refernces

• 1、 Kienzle, Gabriele J.,Reischl, Gerald,Machulla, H.-Juergen. "Electrochemical radiofluorination. 3. Direct labeling of phenylalanine derivatives with [18F]fluoride after anodic oxidation". . p. 259 - 273. Retrieved 2007/10/03.
• 2、 -. "Process for the preparation of substituted N-(indole-2-carbonyl)- glycinamides". . . Retrieved 2008/06/13.