N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide
• CAS No.: 221087-47-4
• Molecular Formula: C10H13 Br N2 O
• Molecular Weight: 257.13
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70432854
• Mol file: 221087-47-4.mol

Synonyms:221087-47-4;N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide;N-(6-Bromopyridin-2-yl)pivalamide;N-(6-Bromopyridin-2-yl)-2,2-dimethylpropionamide;N-(6-Bromo-pyridin-2-yl)-pivaloylamide;6-BROMO-2-PIVALOYLAMINOPYRIDINE;SCHEMBL968790;DIMETHYLSTEARYLAMINEOXIDE;DTXSID70432854;OZYPPHLDZUUCCI-UHFFFAOYSA-N;WIA08747;MFCD08235018;AKOS009546522;MB05941;SS-4338;2-(trimethylacetylamino)-6-bromopyridine;CS-0320667;FT-0682632;A878717;J-523133;N-(6-Bromo-pyridin-2-yl)-2,2-dimethyl-propionamide

Chemical Property of N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 392.7°Cat760mmHg
• Flash Point: 191.3°C
• PSA: 41.99000
• Density: 1.416g/cm³
• LogP: 2.90170
• Storage Temp.: 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 256.02113
• Heavy Atom Count: 14
• Complexity: 213

Purity/Quality:

97% ^*data from raw suppliers

N-(6-Bromopyridin-2-yl)-2,2-dimethylpropanamide >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C(=O)NC1=NC(=CC=C1)Br

Technology Process of N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide

There total 4 articles about N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + pivaloyl chloride (3282-30-2) → N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide (221087-47-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

Reference yield: 84.0%

2,6-Dibromopyridine (626-05-1) + 2,2-dimethylpropionamide (754-10-9) → N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide (221087-47-4)

Guidance literature:

With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine; In toluene; at 70 - 90 ℃; for 48h;

Reference yield:

2-Amino-6-bromopyridine (19798-81-3,1184170-10-2) + aqueous NaCl + pivaloyl chloride (3282-30-2) + sodium hydrogencarbonate (144-55-8) → N-(6-bromopyridin-2-yl)-2,2-dimethylpropanamide (221087-47-4)

Guidance literature:

With hydrogenchloride; triethylamine; In toluene;

upstream raw materials:

2-Amino-6-bromopyridine

pivaloyl chloride

2,6-Dibromopyridine

sodium hydrogencarbonate

Downstream raw materials:

6-(1-naphthylphenylphosphino)-2-pivaloylaminopyridine

benzyl 2-(6-pivalamidopyridin-2-yl)ethylcarbamate

(6-aminopyridin-2-yl)(1-methylpiperidin-4-yl)methanone

Lasmiditan