N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

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Chemical Name:N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide
CAS No.:1426406-57-6
Molecular Formula:C₄₄H₆₁FN₈O₄S
Molecular Weight:817.084
Hs Code.:

N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

Synonyms:N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

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Chemical Property of N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

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Technology Process of N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

There total 11 articles about N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethanamine

: 89889-52-1
6-[6-(biotinamido)caproylamino]caproic N-hydroxysuccinimide ester

: 1426406-57-6
N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

Guidance literature:: With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.01.010

Reference yield:

: 188343-76-2
benzyl 4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidine-1-carboxylate

: 1426406-57-6
N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; hydrogenchloride

2: triethylamine / acetonitrile / 60 °C

3: trifluoroacetic acid / 6.5 h / 20 °C

4: triethylamine / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; acetic acid; triethylamine; trifluoroacetic acid; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.010

Reference yield:

: 85475-10-1
4-(2-chloroacetyl)piperidine-1-carboxylic acid benzyl ester

: 1426406-57-6
N-(2-(4-(5-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyrrol-2-yl)piperidin-1-yl)ethyl)-6-(6-(5-((3aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexanamido)hexanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; dimethyl sulfoxide / 0.58 h / Inert atmosphere

1.2: 2 h / Inert atmosphere

2.1: ammonium acetate; acetic acid / 110 °C

3.1: acetic acid; hydrogenchloride

4.1: triethylamine / acetonitrile / 60 °C

5.1: trifluoroacetic acid / 6.5 h / 20 °C

6.1: triethylamine / dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; ammonium acetate; acetic acid; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.bmcl.2013.01.010