2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester

Base Information

• Chemical Name: 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester
• CAS No.: 38428-13-6
• Molecular Formula: C₂₁H₂₇N₂O₆P
• Molecular Weight: 434.429
• Mol file: 38428-13-6.mol

Synonyms:2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester

Chemical Property of 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester

There total 6 articles about 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

diethyl 1-aminophenylmethylphosphonate (16814-08-7,42077-95-2,42077-97-4) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester (38428-13-6)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; for 12h; 0 deg C to rt;

Reference yield:

diethyl ether of α-(N-benzyloxycarbonyl)aminobenzylphosphonic acid (38428-05-6) → 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester (38428-13-6)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

2: 77 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 0 deg C to rt

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

benzaldehyde (100-52-7) → 2-Benzyloxy-carbonylglycylamino-benzylphosphonsaeure-diaethylester (38428-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetyl chloride / 6 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 760 Torr / Ambient temperature

3: 77 percent / N-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 12 h / 0 deg C to rt

With hydrogen; benzotriazol-1-ol; acetyl chloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane;

upstream raw materials:

diethyl 1-aminophenylmethylphosphonate

N-(Benzyloxycarbonyl)glycine

Diethyl-α-Aminobenzylphosphonato-hydrobromid

diethyl ether of α-(N-benzyloxycarbonyl)aminobenzylphosphonic acid

Downstream raw materials:

N-Glycyl-α-aminobenzylphosphonsaeure

α-Glycylamino-benzylphosphonsaeure-diaethylester