N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

Base Information

Chemical Name:N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide
CAS No.:103373-60-0
Molecular Formula:C₂₄H₁₇FN₄OS
Molecular Weight:428.49
Hs Code.:

Synonyms:N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

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Chemical Property of N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

Chemical Property:

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Technology Process of N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

There total 3 articles about N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103373-52-0
(3RS)-3-benzyloxycarbonylamino-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one

: 103373-60-0
N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Lawesson's reagent / toluene / 1.5 h / Heating

2: HBr gas / CH₂Cl₂; acetic acid / 6 h

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, Et₃N / dimethylformamide / 18 h / Ambient temperature; pH 8

With Lawessons reagent; hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00396a028

Reference yield:

: 103373-53-1
<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>carbamic acid phenyl methyl ester

: 103373-60-0
N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: HBr gas / CH₂Cl₂; acetic acid / 6 h

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride, Et₃N / dimethylformamide / 18 h / Ambient temperature; pH 8

With hydrogen bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00396a028

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 103373-59-7
1,3-dihydro-5-(2-fluorophenyl)-3-(RS)-amino-2H-1,4-benzodiazepin-2-thione

: 103373-60-0
N-<5-(2-fluorophenyl)-2,3-dihydro-2-thioxo-1H-1,4-benzodiazepin-3-yl>-1H-indole-2-carboxamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; for 18h; Ambient temperature; pH 8;
DOI:10.1021/jm00396a028