Methyl 2-methyl-4,5-dihydrofuran-3-carboxylate

Base Information

• Chemical Name: Methyl 2-methyl-4,5-dihydrofuran-3-carboxylate
• CAS No.: 32595-98-5
• Molecular Formula: C₇H₁₀O₃
• Molecular Weight: 142.155
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID70498738
• Nikkaji Number: J403.650F
• Wikidata: Q82348976
• Mol file: 32595-98-5.mol

Synonyms:32595-98-5;METHYL 2-METHYL-4,5-DIHYDROFURAN-3-CARBOXYLATE;2-METHYL-4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID METHYL ESTER;methyl 5-methyl-2,3-dihydrofuran-4-carboxylate;2-METHYL-4,5-DIHYDRO-FURAN-3-CARBOXYLICACIDMETHYLESTER;methyl2-methyl-4,5-dihydrofuran-3-carboxylate;DTXSID70498738;MFCD09032500;AKOS006291599;AS-70418;W15954

Chemical Property of Methyl 2-methyl-4,5-dihydrofuran-3-carboxylate

Chemical Property:

• Vapor Pressure: 0.606mmHg at 25°C
• Melting Point: 28-29 °C
• Refractive Index: 1.469
• Boiling Point: 188.2°C at 760 mmHg
• Flash Point: 69.1°C
• PSA: 35.53000
• Density: 1.122g/cm³
• LogP: 0.85370
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 142.062994177
• Heavy Atom Count: 10
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

2-METHYL-4,5-DIHYDRO-FURAN-3-CARBOXYLIC ACID METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(CCO1)C(=O)OC

Technology Process of Methyl 2-methyl-4,5-dihydrofuran-3-carboxylate

There total 5 articles about Methyl 2-methyl-4,5-dihydrofuran-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

Methyl (3aβ,9aβ)-2,3,3a,9a-tetrahydro-9a-methyl-4-oxo-4H-furo<2,3-b><1>benzopyran-3a-carboxylate (138494-87-8) → 4,5-Dihydro-2-methyl-3-furancarbonsaeure-methylester (32595-98-5)

Guidance literature:

With sodium methylate; In methanol; for 24h; Heating;

DOI:10.1016/S0040-4020(01)80889-9

Reference yield: 20.0%

methanol (67-56-1) + 3-acetyl-2-oxo-4,5-dihydrofuran (517-23-7,594837-91-9,98634-97-0,313643-49-1) → 4,5-Dihydro-2-methyl-3-furancarbonsaeure-methylester (32595-98-5)

Guidance literature:

With hydrogenchloride; 1.) reflux, 12 h, 2.) r.t., 3 d;

DOI:10.1021/jo00012a040

Reference yield:

methyl 2-methylchromone-3-carboxylate (51751-33-8) → 4,5-Dihydro-2-methyl-3-furancarbonsaeure-methylester (32595-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 24 percent / anhydr. K₂CO₃ / acetone / 48 h / Heating

2: 64 percent / NaOMe / methanol / 24 h / Heating

With sodium methylate; potassium carbonate; In methanol; acetone;

DOI:10.1016/S0040-4020(01)80889-9

upstream raw materials:

methanol

3-acetyl-2-oxo-4,5-dihydrofuran

Methyl (3aβ,9aβ)-2,3,3a,9a-tetrahydro-9a-methyl-4-oxo-4H-furo<2,3-b><1>benzopyran-3a-carboxylate

hydrogenchloride