Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester
• CAS No.: 179676-37-0
• Molecular Formula: C₅₂H₅₉N₇O₁₄
• Molecular Weight: 1006.08
• Mol file: 179676-37-0.mol

Synonyms:Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester

Chemical Property of Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester

There total 3 articles about Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-nitrophenyl)ethoxycarbonyl chloride (88091-68-3) → Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester (179676-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / pyridine; CH₂Cl₂ / 1.67 h / -10 °C

2: 1.) 4-dimethylaminopyridine; 2.) N-<3-dimethylamino)propyl>-N'ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 18 h; 2.) CH₂Cl₂, 5 h

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; dichloromethane;

DOI:10.1002/hlca.19960790304

Reference yield:

3'-deoxy-N6-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine (112237-60-2) → Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester (179676-37-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / pyridine; CH₂Cl₂ / 1.67 h / -10 °C

2: 1.) 4-dimethylaminopyridine; 2.) N-<3-dimethylamino)propyl>-N'ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 18 h; 2.) CH₂Cl₂, 5 h

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In pyridine; dichloromethane;

DOI:10.1002/hlca.19960790304

Reference yield:

succinic acid anhydride (108-30-5) + RETINOL (68-26-8) + Carbonic acid (2S,4R,5R)-4-hydroxy-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(4-nitro-phenyl)-ethyl ester (177084-28-5) → Succinic acid (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-2,4,6,8-tetraenyl ester (2R,3R,5S)-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-5-[2-(4-nitro-phenyl)-ethoxycarbonyloxymethyl]-tetrahydro-furan-3-yl ester (179676-37-0)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 18 h; 2.) CH₂Cl₂, 5 h;

DOI:10.1002/hlca.19960790304

upstream raw materials:

succinic acid anhydride

RETINOL

Carbonic acid (2S,4R,5R)-4-hydroxy-5-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-2-ylmethyl ester 2-(4-nitro-phenyl)-ethyl ester

2-(4-nitrophenyl)ethoxycarbonyl chloride