tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate
CAS No.:1402609-36-2
Molecular Formula:C₂₉H₃₀N₄O₃
Molecular Weight:482.582
Hs Code.:

Synonyms:tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

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Technology Process of tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

There total 5 articles about tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1402609-35-1
tert-butyl {1-[4-(6-{4-[methoxy(methyl)carbamoyl]}-3-phenyl-imidazo[1,2-b]pyridazin-2-yl)phenyl]cyclobutyl}carbamate

: 676-58-4
methylmagnesium chloride

: 1402609-36-2
tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃; for 17h; Inert atmosphere;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402609-36-2
tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 20 h / Reflux

3.1: sodium hydroxide; water / methanol / 24 h / 20 °C

3.2: pH 4

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 21 h / 20 °C

5.1: tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; pyridinium hydrobromide perbromide; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1402608-81-4
ethyl 2-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-3-phenylimidazo[1,2-b]pyridazine-6-carboxylate

: 1402609-36-2
tert-butyl (1-{4-[6-(4-acetylphenyl)-3-phenylimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 24 h / 20 °C

1.2: pH 4

2.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 21 h / 20 °C

3.1: tetrahydrofuran / 17 h / 0 - 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;