N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide

Base Information

• Chemical Name: N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide
• CAS No.: 185508-80-9
• Molecular Formula: C₁₃H₂₀N₂O₂
• Molecular Weight: 236.314
• Mol file: 185508-80-9.mol

Synonyms:N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide

Chemical Property of N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide

There total 1 articles about N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

N-methylglycine methylester (5473-12-1) + (1R,2R)-pseudoephedrine (321-97-1,7009-81-6,90-83-5,6912-63-6) → N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide (185508-80-9)

Guidance literature:

With lithium methanolate; lithium chloride; In tetrahydrofuran; 0 deg C, 1.5 h; 23 deg C, 12 h;

DOI:10.1021/ja9624073

Reference yield:

benzyl bromide (100-39-0) + N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide (185508-80-9) → (R)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-3-phenyl-propionamide + (S)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-3-phenyl-propionamide (185508-99-0)

Guidance literature:

With (2-hydroxyethyl)(methyl)amine; n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1021/ja9624073

Reference yield:

ethyl iodide (75-03-6) + N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-acetamide (185508-80-9) → (S)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-butyramide + (R)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-butyramide

Guidance literature:

With (2-hydroxyethyl)(methyl)amine; n-butyllithium; lithium chloride; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1021/ja9624073

upstream raw materials:

N-methylglycine methylester

(1R,2R)-pseudoephedrine

Downstream raw materials:

(S)-N-((1R,2R)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-N-methyl-2-methylamino-3-phenyl-propionamide