Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

Base Information

• Chemical Name: Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)
• CAS No.: 215254-90-3
• Molecular Formula: C₈H₁₆N₂O₃
• Molecular Weight: 188.227
• Mol file: 215254-90-3.mol

Synonyms:Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property of Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.451
• Boiling Point: 370.927°C at 760 mmHg
• Flash Point: 178.131°C
• PSA: 74.41000
• Density: 1.051g/cm³
• LogP: 1.30180

Purity/Quality:

tert-butylN-(2-formamidoethyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI)

There total 3 articles about Carbamic acid, [2-(formylamino)ethyl]-, 1,1-dimethylethyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-BOC-1,2-diaminoethane (57260-73-8) + formic acid ethyl ester (109-94-4) → (N-tert-butyloxycarbonyl)-N’-formylethylenediamine (215254-90-3)

Guidance literature:

for 18h; Reflux; Inert atmosphere;

DOI:10.1039/c5ob01604e

Reference yield: 90.0%

formic acid (64-18-6) + N-BOC-1,2-diaminoethane (57260-73-8) → (N-tert-butyloxycarbonyl)-N’-formylethylenediamine (215254-90-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1055/s-2003-39391

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (N-tert-butyloxycarbonyl)-N’-formylethylenediamine (215254-90-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / tetrahydrofuran / 24.5 h / 0 - 20 °C

2: 90 percent / DCC / CH₂Cl₂ / 20 °C

With dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-2003-39391

upstream raw materials:

formic acid

N-BOC-1,2-diaminoethane

di-tert-butyl dicarbonate

formic acid ethyl ester

Downstream raw materials:

(1-{[[1-(2-tert-butoxycarbonylamino-ethylcarbamoyl)-3-methyl-butyl]-(3-methyl-butyl)-carbamoyl]-methyl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-carbamic acid benzyl ester

3-<(tert-butoxycarbonyl)amino>propionitrile