Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate

Base Information

Chemical Name:Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate
CAS No.:210697-19-1
Molecular Formula:C₉H₁₁FN₂O₂
Molecular Weight:198.197
Hs Code.:
DSSTox Substance ID:DTXSID101219863
Mol file:210697-19-1.mol

Synonyms:210697-19-1;DTXSID101219863;Methyl 2-(ethylamino)-6-fluoro-3-pyridinecarboxylate;3-pyridinecarboxylic acid,2-(ethylamino)-6-fluoro-,methyl ester

Suppliers and Price of Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate

Chemical Property:

Boiling Point:280.8±40.0 °C(Predicted)
PKA:0.96±0.10(Predicted)
PSA：51.22000
Density:1.233±0.06 g/cm3(Predicted)
LogP:1.51210
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:198.08045576
Heavy Atom Count:14
Complexity:201

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCNC1=C(C=CC(=N1)F)C(=O)OC

Technology Process of Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate

There total 3 articles about Methyl 2-(ethylamino)-6-fluoropyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 557-66-4
ethanamine hydrochloride

: 117671-02-0
methyl 2,6-difluoro-3-pyridinecarboxylate

: 210697-19-1
methyl 2-ethylamino-6-fluoropyridine-3-carboxyalate

: 210697-18-0
methyl 6-ethylamino-2-fluoropyridine-3-carboxylate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 5 ℃; for 1h;
DOI:10.1021/jm020270n

Reference yield:

: 75-04-7,85404-22-4
ethylamine

: 117671-02-0
methyl 2,6-difluoro-3-pyridinecarboxylate

: 210697-19-1
methyl 2-ethylamino-6-fluoropyridine-3-carboxyalate

: 210697-18-0
methyl 6-ethylamino-2-fluoropyridine-3-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 5 ℃;
DOI:10.1016/S0960-894X(98)00258-3

Reference yield:

: 171178-50-0
2,6-difluoronicotinic acid

: 210697-19-1
methyl 2-ethylamino-6-fluoropyridine-3-carboxyalate

Guidance literature:: Multi-step reaction with 2 steps

1: conc. H₂SO₄

2: dimethylformamide / 5 °C

With sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00258-3