3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI)
• CAS No.: 210697-18-0
• Molecular Formula: C₉H₁₁FN₂O₂
• Molecular Weight: 198.197
• Mol file: 210697-18-0.mol

Synonyms:3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI)

Chemical Property of 3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI)

Chemical Property:

• PSA: 54.45000
• LogP: 0.86100

Purity/Quality:

99%+ ^*data from raw suppliers

methyl6-(ethylamino)-2-fluoropyridine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI)

There total 3 articles about 3-Pyridinecarboxylicacid,6-(ethylamino)-2-fluoro-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethanamine hydrochloride (557-66-4) + methyl 2,6-difluoro-3-pyridinecarboxylate (117671-02-0) → methyl 2-ethylamino-6-fluoropyridine-3-carboxyalate (210697-19-1) + methyl 6-ethylamino-2-fluoropyridine-3-carboxylate (210697-18-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 5 ℃; for 1h;

DOI:10.1021/jm020270n

Reference yield:

2,6-difluoronicotinic acid (171178-50-0) → methyl 6-ethylamino-2-fluoropyridine-3-carboxylate (210697-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄

2: dimethylformamide / 5 °C

With sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00258-3

Reference yield:

ethylamine (75-04-7,85404-22-4) + methyl 2,6-difluoro-3-pyridinecarboxylate (117671-02-0) → methyl 2-ethylamino-6-fluoropyridine-3-carboxyalate (210697-19-1) + methyl 6-ethylamino-2-fluoropyridine-3-carboxylate (210697-18-0)

Guidance literature:

In N,N-dimethyl-formamide; at 5 ℃;

DOI:10.1016/S0960-894X(98)00258-3

upstream raw materials:

ethylamine

methyl 2,6-difluoro-3-pyridinecarboxylate

ethanamine hydrochloride

2,6-difluoronicotinic acid

Downstream raw materials:

methyl 6-ethylamino-2-methoxypyridine-3-carboxylate

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