N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

Base Information

Chemical Name:N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide
CAS No.:1262859-21-1
Molecular Formula:C₁₁H₁₂BrClN₂O₄
Molecular Weight:351.584
Hs Code.:

Synonyms:N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

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Chemical Property of N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

Chemical Property:

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Technology Process of N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

There total 8 articles about N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-20-0
(R)-2-Amino-2-(3-bromo-5-nitro-phenyl)-propan-1-ol

: 79-04-9
chloroacetyl chloride

: 1262859-21-1
N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

Guidance literature:: With potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 19h; Inert atmosphere;

Reference yield:

: 127413-59-6
1-(3-bromo-5-nitrophenyl)ethanone

: 1262859-21-1
N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

1.2: Cooling with ice

2.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

3.1: hydrogenchloride / toluene / 4 h / Reflux

4.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 355134-13-3
3-bromo-5-nitrobenzaldehyde

: 1262859-21-1
N-[(R)-1-(3-Bromo-5-nitro-phenyl)-2-hydroxy-1-methyl-ethyl]-2-chloro-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: titanium tetrachloride / tetrahydrofuran; dichloromethane / 1 h / -78 - -30 °C

2.1: manganese(IV) oxide / 1,4-dioxane / 17 h / Reflux

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2.5 h / Reflux

3.2: Cooling with ice

4.1: cesium fluoride / tetrahydrofuran; hexane / 4 h / -50 - 0 °C

5.1: hydrogenchloride / toluene / 4 h / Reflux

6.1: diborane / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

7.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 19 h / 0 °C / Inert atmosphere

With hydrogenchloride; manganese(IV) oxide; potassium carbonate; N-ethyl-N,N-diisopropylamine; cesium fluoride; diborane; titanium(IV) tetraethanolate; titanium tetrachloride; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;