(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Base Information

Chemical Name:(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one
CAS No.:1610539-69-9
Molecular Formula:C₁₈H₁₆N₂O₃
Molecular Weight:308.337
Hs Code.:

Synonyms:(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

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Chemical Property of (E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

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Technology Process of (E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

There total 3 articles about (E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 78-94-4,25038-87-3
methyl vinyl ketone

: 77250-70-5
N-(2-(4-methoxyphenyl)-2-oxoethyl)picolinamide

: 1610539-69-9
(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Guidance literature:: With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In para-xylene; at 120 ℃; for 5h; stereoselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1039/c4cc02322f

Reference yield:

: 98-98-6
2-Picolinic acid

: 1610539-69-9
(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / para-xylene / 5 h / 120 °C / Sealed tube; Inert atmosphere

With silver hexafluoroantimonate; oxalyl dichloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N,N-dimethyl-formamide; In dichloromethane; para-xylene;
DOI:10.1039/c4cc02322f

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 1610539-69-9
(E)-6-(4-methoxybenzyl)-5-(2-oxopropylidene)-5H-pyrrolo[3,4-b]pyridin-7(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver hexafluoroantimonate / para-xylene / 5 h / 120 °C / Sealed tube; Inert atmosphere

With silver hexafluoroantimonate; oxalyl dichloride; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; N,N-dimethyl-formamide; In dichloromethane; para-xylene;
DOI:10.1039/c4cc02322f