5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

Base Information

Chemical Name:5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid
CAS No.:160388-23-8
Molecular Formula:C₃₇H₅₄N₄O₉
Molecular Weight:698.857
Hs Code.:

Synonyms:5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

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Chemical Property of 5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

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Technology Process of 5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

There total 7 articles about 5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 108-30-5
succinic acid anhydride

: 160388-22-7
7,18-Bis(benzyloxy)-1-(tert-butoxycarbonyl)-8,11-dioxo-1,7,12,18-tetraazaoctadecane

: 160388-23-8
5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

Guidance literature:: With pyridine; at 81 ℃; for 2h;
DOI:10.1021/jo00106a022

Reference yield:

: 129245-21-2
O-benzyl-N-(5-aminopentyl)-N-(tert-butoxycarbonyl)hydroxylamine

: 160388-23-8
5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: TFA / CH₂Cl₂ / 30 h / Ambient temperature

2: tetrahydrofuran / 24 h

3: 88 percent / pyridine / 1.5 h / 80 - 86 °C

4: CH₂Cl₂ / 1 h

5: CH₂Cl₂ / 12 h

6: 81 percent / pyridine / 2 h / 81 °C

With pyridine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00106a022

Reference yield:

: 160388-21-6
N-(Benzyloxy)-1,5-pentanediamine

: 160388-23-8
5,16-Bis(benzyloxy)-22-(tert-butoxycarbonyl)-4,12,15-trioxo-5,11,16,22-tetraazadocosanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 24 h

2: 88 percent / pyridine / 1.5 h / 80 - 86 °C

3: CH₂Cl₂ / 1 h

4: CH₂Cl₂ / 12 h

5: 81 percent / pyridine / 2 h / 81 °C

With pyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00106a022