tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate
CAS No.:1124214-52-3
Molecular Formula:C₂₆H₃₆N₆O₄
Molecular Weight:496.61
Hs Code.:

Synonyms:tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

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Chemical Property of tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

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Technology Process of tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

There total 9 articles about tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide dihydrochloride

: 891782-63-1
5-((tert-butoxycarbonyl)amino)pyrazine-2-carboxylic acid

: 1124214-52-3
tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

Guidance literature:: 5-((tert-butoxycarbonyl)amino)pyrazine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

N-tert-butyl-3-(piperazin-1-ylmethyl)benzamide dihydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 122-05-4
2,5-pyrazinedicarboxylic acid

: 1124214-52-3
tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 48 h / 80 °C / sealed vessel

2.1: hydrazine hydrate / ethanol / 20 °C

3.1: hydrogenchloride; sodium nitrite / dichloromethane; water / 1 h / 0 - 10 °C

4.1: toluene / 1 h / Reflux

5.1: water; potassium hydroxide / methanol / 20 °C

5.2: pH 2

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 20 °C

With hydrogenchloride; water; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; sodium nitrite; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124214-52-3
tert-butyl 5-(4-(3-(tert-butylcarbamoyl)benzyl)piperazine-1-carbonyl)pyrazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethanol / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;