5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine

Base Information

• Chemical Name: 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine
• CAS No.: 137976-95-5
• Molecular Formula: C₂₇H₂₅N₃O₄
• Molecular Weight: 455.513

Synonyms:5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine

Chemical Property of 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine

There total 4 articles about 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-⁽⁵⁾1H-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one (1127-74-8) → 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-(5)1H-benzazepine (137976-95-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) hydroxylamine*HCl, 2.) pyridine / 1.) reflux, 2.5, 2.) RT, 3 h

With pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm960133o

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-(5)1H-benzazepine (137976-95-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

3: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) hydroxylamine*HCl, 2.) pyridine / 1.) reflux, 2.5, 2.) RT, 3 h

With pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm960133o

Reference yield:

1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one (137975-89-4) → 5-(acetoxyimino)-1-{4-[(2-methylbenzoyl)amino]benzoyl}-2,3,4,5-tetrahydro-(5)1H-benzazepine (137976-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol / 5 h / 760 Torr / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) hydroxylamine*HCl, 2.) pyridine / 1.) reflux, 2.5, 2.) RT, 3 h

With pyridine; hydroxylamine hydrochloride; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm960133o

upstream raw materials:

1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one

4-nitro-benzoyl chloride

1-(4-aminobenzoyl)-2,3,4,5-tetrahydro1H-1-benzazepin-5-one

1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one

Downstream raw materials:

N-[4-(5-Amino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

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