137975-89-4

Basic information

• Product Name: 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-
• Synonyms: 1-(4-nitrobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one;1-(4-nitrobenzoyl)-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-5H-1-benzazepin-5-one;5H-1-Benzazepin-5-one,1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)
• CAS NO: 137975-89-4
• Molecular Formula: C17H14N2O4
• Molecular Weight: 310.309
• Mol File: 137975-89-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-(137975-89-4)
• EPA Substance Registry System: 5H-1-Benzazepin-5-one, 1,2,3,4-tetrahydro-1-(4-nitrobenzoyl)-(137975-89-4)

Safety Data

• Hazardous Substances Data: 137975-89-4(Hazardous Substances Data)

Upstream product

• 1127-74-8 1,2,3,4-tetrahydro-5H-benzo[b] azepin-5-one 
• 122-04-3 4-nitro-benzoyl chloride 
• 3460-11-5 4-nitrobenzanilide 
• 62-23-7 4-nitro-benzoic acid 
• 62-53-3 aniline 

Downstream Products

• 168626-71-9 2-methyl-6-(4-nitrobenzoyl)-1,4,5,6-tetrahydroimidazo-[4,5-d][1]benzazepine 
• 200122-32-3 5-chloro-1-(4-nitrobenzoyl)-2,3-dihydro-1 H-benzo[b]azepine-4-carbaldehyde 
• 200122-34-5 ethyl 6-(4-aminobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate 
• 200122-35-6 6-(4-nitrobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylic acid 
• 200122-33-4 ethyl 6-(4-nitrobenzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxylate 
• 168626-93-5 4'-(2-methyl-5,6-dihydro-4H-oxazolo[4,5-d][1]benzoazepine-6-carbonyl)-2-phenylbenzanilide 
• 261787-69-3 4'-(4-bromo-5-oxo-2,3,4,5-tetrahydro-1H-1-benzoazepine-1-carbonyl)-2-phenylbenzanilide 
• 168626-54-8 N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide 
• 195531-22-7 {4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}amine 

Relevant articles and documents

Tolvaptan-Type Vasopressin Receptor Ligands: Important Role of Axial Chirality in the Active Form

The anti and syn isomers of tolvaptan-type compounds, N-benzoyl-5-hydroxy-1-benzazepines (5a-c), were prepared in a stereocontrolled manner by biasing the conformation with a methyl group at C9 and C6, respectively, and the enantiomeric forms were separat

Novel 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative

There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and for the prevention of disease associated with RSV infection. (Formula (I))

Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1] benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: An Arginine Vasopressin Antagonist

A novel, reliable, and cost-effective synthetic route to N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl] -phenyl}biphenyl-2-carboxamide monohydrochloride (1, YM087), a potent Arginine vasopressin antagonist, has been developed. Using moisture-controlled potassium carbonate, imidazole formation from α-bromoketone furnished imidazobenzazepine, avoiding potential oxazole-ring formation. Catalytic reduction of nitro imidazobenzazepine afforded the corresponding amine in high yields. Treatment of the imidazole-containing amine directly, with a carbonyl chloride, afforded the target amide circumventing protection of the imidazole.