ACETONYLMALONIC ACID DIMETHYL ESTER

Base Information

• Chemical Name: ACETONYLMALONIC ACID DIMETHYL ESTER
• CAS No.: 24889-15-4
• Molecular Formula: C8H12O5
• Molecular Weight: 188.18
• Hs Code.: 2918300090
• Mol file: 24889-15-4.mol

Synonyms:Propanedioic acid, (2-oxopropyl)-,dimethyl ester (9CI);Dimethyl acetonylmalonate;Malonicacid, acetonyl-, dimethyl ester (8CI);

Chemical Property of ACETONYLMALONIC ACID DIMETHYL ESTER

Chemical Property:

• Refractive Index: 1.43
• Boiling Point: 262.739 °C at 760 mmHg
• Flash Point: 111.135 °C
• PSA: 69.67000
• Density: 1.14 g/cm³
• LogP: -0.07230

Purity/Quality:

98%min ^*data from raw suppliers

DIMETHYL2-OXOPROPYLMALONATE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETONYLMALONIC ACID DIMETHYL ESTER

There total 4 articles about ACETONYLMALONIC ACID DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

methanol (67-56-1) + dimethyl diazomalonate (6773-29-1) → dimethyl 2-hydroxymalonate (34259-29-5) + dimethyl methoxymalonate (5018-30-4) + methyl 2-(methoxycarbonyl)-4-oxopentanonate (24889-15-4) + methyl 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylate (62609-79-4)

Guidance literature:

In acetone; for 10h; Irradiation;

DOI:10.1021/ja00209a034

Reference yield: 31.0%

dimethyl diazomalonate (6773-29-1) + acetone (67-64-1) → dimethyl 2-hydroxymalonate (34259-29-5) + dimethyl methoxymalonate (5018-30-4) + methyl 2-(methoxycarbonyl)-4-oxopentanonate (24889-15-4) + methyl 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylate (62609-79-4)

Guidance literature:

for 10h; Product distribution; Irradiation; reaction in the presence of benzophenone;

DOI:10.1021/ja00209a034

Reference yield: 2.0%

dimethyl diazomalonate (6773-29-1) + acetone (67-64-1) → dimethyl 2-hydroxymalonate (34259-29-5) + methyl 2-(methoxycarbonyl)-4-oxopentanonate (24889-15-4) + methyl 2,2-dimethyl-5-oxo-1,3-dioxolane-4-carboxylate (62609-79-4) + malonic acid dimethyl ester (108-59-8)

Guidance literature:

benzophenone; for 10h; Irradiation;

DOI:10.1021/ja00209a034

upstream raw materials:

methanol

dimethyl diazomalonate

acetone

dimethyl isopropylidenemalonate

Downstream raw materials:

(1S,2R,5R)-dimethyl 5-methyl-7-oxo-2-phenyl-6-oxabicyclo[3.2.0]heptane-3,3-dicarboxylate

Refernces

• 1、 L'Esperance, Robert P.,Ford, Thomas M.,Jones, Maitland. "Reaction of Dicarbomethoxycarbene with Acetaldehyde and Simple Ketones". . p. 209 - 213. Retrieved 2007/10/02.