4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

Base Information

Chemical Name:4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline
CAS No.:1578246-35-1
Molecular Formula:C₂₈H₃₃N₃O₂Si
Molecular Weight:471.674
Hs Code.:

Synonyms:4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

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Chemical Property of 4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

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Technology Process of 4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

There total 1 articles about 4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 461699-81-0
2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 1578246-34-0
1-(2-(tert-butyldiphenylsilyloxy)ethyl)-4-iodo-1H-pyrazole

: 1578246-35-1
4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In tetrahydrofuran; water; at 60 ℃; for 18h;

Reference yield: 91.0%

: 64-18-6
formic acid

: 1578246-35-1
4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1578246-36-2
N-(4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyphenyl)formamide

Guidance literature:: formic acid; 4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline; for 3h; Reflux;

With triethylamine; In methanol; at 20 ℃; for 1h;

tert-butylchlorodiphenylsilane; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 1578246-35-1
4-(1-(2-(tert-butyldiphenylsilyloxy)ethyl)-1H-pyrazol-4-yl)-2-methoxyaniline

: 1578244-00-4
2-(4-(4-((8-(cyclohexylamino)pyrido[3,4-d]pyrimidin-2-yl)amino)-3-methoxyphenyl)-1H-pyrazol-1-yl)ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 3 h / Reflux

1.2: 1 h / 20 °C

1.3: 18 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 - 20 °C

2.2: 18 h / 0 - 20 °C

2.3: 1 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;