6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

Base Information

Chemical Name:6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole
CAS No.:145508-57-2
Molecular Formula:C₂₁H₂₄N₂O₂
Molecular Weight:336.434
Hs Code.:

Synonyms:6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

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Chemical Property of 6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

Chemical Property:

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Technology Process of 6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

There total 8 articles about 6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 145508-55-0
6-methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

: 145508-57-2
6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

Guidance literature:: With hydrogen bromide; at 110 ℃; for 16h;

Reference yield:

: 144-55-8
sodium hydrogencarbonate

: 145508-55-0
6-methoxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

: 145508-57-2
6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

Guidance literature:: In hydrogen bromide;

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 145508-57-2
6-hydroxy-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / Et₃N / dioxane; H₂O / 16 h / 0 - 20 °C

2: 93 percent / LiAlH₄ / tetrahydrofuran / 16 h / 0 - 20 °C

3: 92 percent / PPh₃, I₂, pyridine / benzene / 1.5 h / Heating

4: 80 percent / LDA / tetrahydrofuran / 0.42 h / -78 °C

5: 1.) TFA, 2.) Et₃N / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 15 h

6: 57 percent / 48percent aq. HBr / 16 h / 110 °C

With pyridine; lithium aluminium tetrahydride; hydrogen bromide; iodine; triethylamine; triphenylphosphine; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; water; benzene;