methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

Base Information

Chemical Name:methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate
CAS No.:264613-49-2
Molecular Formula:C₂₂H₃₀O₃SSi
Molecular Weight:402.63
Hs Code.:

Synonyms:methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

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Chemical Property of methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

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Technology Process of methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

There total 6 articles about methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 103-26-4,1754-62-7
Methyl cinnamate

: 153123-09-2
(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide

: 3-Phenyl-4-((R)-toluene-4-sulfinyl)-5-trimethylsilanyl-pentanoic acid methyl ester

: 264613-49-2
methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

Guidance literature:: (R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

Methyl cinnamate; In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1021/jo991635n

Reference yield: 90.0%

: 103-26-4,1754-62-7
Methyl cinnamate

: 78-84-2
isobutyraldehyde

: 153123-09-2
(R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide

: 264613-49-2
methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

: methyl (R_S,2R,3R,4R)-2-[(R)-1-hydroxy-2-methylpropyl]-3-phenyl-4-(p-tolylsulfinyl)-5-trimethylsilylpentanoate

Guidance literature:: (R_S)-p-Tolyl β-(trimethylsilyl)ethyl sulfoxide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

Methyl cinnamate; In tetrahydrofuran; at -78 ℃; for 0.25h;

isobutyraldehyde; In tetrahydrofuran; at -78 - 0 ℃; Further stages.;
DOI:10.1021/jo991635n

Reference yield: 75.0%

: 103-26-4,1754-62-7
Methyl cinnamate

: p-tolyl α-lithio-β-(trimethylsilyl)ethyl sulfoxide

: 74-88-4
methyl iodide

: 2-Methyl-3-phenyl-4-((R)-toluene-4-sulfinyl)-5-trimethylsilanyl-pentanoic acid methyl ester

: 264613-49-2
methyl (3R,4R)-3-phenyl-4-[(R)-p-tolylsulfinyl]-5-(trimethylsilyl)pentanoate

: 264613-69-6
methyl (R_S,2S,3R,4R)-2-methyl-3-phenyl-4-(p-tolylsulfinyl)-5-trimethylsilylpentanoate

Guidance literature:: Methyl cinnamate; p-tolyl α-lithio-β-(trimethylsilyl)ethyl sulfoxide; In tetrahydrofuran; at -78 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at -78 - 0 ℃; for 0.5h;
DOI:10.1021/jo991635n