Ethyl cis-3-(acetamido)-2-butenoate

Base Information

• Chemical Name: Ethyl cis-3-(acetamido)-2-butenoate
• CAS No.: 23652-56-4
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Mol file: 23652-56-4.mol

Synonyms:2-Butenoicacid, 3-(acetylamino)-, ethyl ester, (Z)-;Crotonic acid, 3-acetamido-, ethylester, (Z)- (8CI);N-((Z)-3-Ethoxy-1-methyl-3-oxo-1-propenyl)acetamide;

Chemical Property of Ethyl cis-3-(acetamido)-2-butenoate

Chemical Property:

• Boiling Point: 317.034 °C at 760 mmHg
• Flash Point: 145.537 °C
• PSA: 55.40000
• Density: 1.048 g/cm³
• LogP: 0.98030

Purity/Quality:

99% ^*data from raw suppliers

(Z)-Ethyl3-acetamidobut-2-enoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl cis-3-(acetamido)-2-butenoate

There total 19 articles about Ethyl cis-3-(acetamido)-2-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

acetic anhydride (108-24-7) + ethyl 3-aminobut-2-enoate (626-34-6) → ethyl (Z)-β-acetylaminobut-2-enoate (23652-67-7,55572-47-9,23652-56-4)

Guidance literature:

at 90 ℃; for 0.0166667h; Sealed tube; Microwave irradiation; Green chemistry;

DOI:10.21577/0103-5053.20160265

Reference yield: 62.0%

acetamide (60-35-5) + (Z)-3-iodo-but-2-enoic acid ethyl ester (34450-61-8,34450-62-9) → ethyl (Z)-β-acetylaminobut-2-enoate (23652-67-7,55572-47-9,23652-56-4)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 70 ℃; for 6h;

DOI:10.1021/ol035355c

Reference yield: 61.0%

acetamide (60-35-5) + ethyl acetoacetate (141-97-9) → ethyl (Z/E)-β-acetylaminobut-2-enoate (23652-56-4,23652-67-7,55572-47-9)

Guidance literature:

With boron trifluoride diethyl etherate; In cyclohexane; for 24h; Reagent/catalyst; Reflux;

upstream raw materials:

acetic anhydride

ethyl aminocrotonate

acetamide

ethyl acetoacetate

Downstream raw materials:

ethyl 2-(1-acetyl-4,5-diphenyl-1H-pyrrol-2-yl)ethanoate

(R)-2-ethyl-N-(1-methoxypropan-2-yl)-6-methylaniline

methyl (E)-3-acetamido-2-butenoate

2,4-dimethyloxazole-5-ylcarboxylate ethyl ester