N,N-Diethyl-2,5-dimethyoxyaniline

Base Information

• Chemical Name: N,N-Diethyl-2,5-dimethyoxyaniline
• CAS No.: 2628-49-1
• Molecular Formula: C12H19 N O2
• Molecular Weight: 209.288
• Mol file: 2628-49-1.mol

Synonyms:Aniline,N,N-diethyl-2,5-dimethoxy- (7CI); N,N-Diethylaminohydroquinone dimethyl ether

Chemical Property of N,N-Diethyl-2,5-dimethyoxyaniline

Chemical Property:

• Boiling Point: 93 °C (0.3 mmHg)
• PSA: 21.70000
• LogP: 2.55000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Diethyl-2,5-dimethyoxyaniline

There total 4 articles about N,N-Diethyl-2,5-dimethyoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl bromide (74-96-4) + 2,5-dimethoxyaniline (102-56-7,102526-87-4) → 1,4-dimethoxy-2-(N,N-diethylamino)benzene (2628-49-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 - 50 ℃;

DOI:10.1039/c2cc32009f

Reference yield: 66.0%

ethyl iodide (75-03-6) + 2,5-dimethoxyaniline (102-56-7,102526-87-4) → 1,4-dimethoxy-2-(N,N-diethylamino)benzene (2628-49-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 37h;

Reference yield:

1-bromo-2,5-dimethoxybenzene (25245-34-5) + diethylamine (109-89-7) → 1,4-dimethoxy-2-(N,N-diethylamino)benzene (2628-49-1)

Guidance literature:

With potassium amide; Yield given. Multistep reaction; 1.) liq. NH₃, 2.) 1 h;

DOI:10.1021/jo00208a048

upstream raw materials:

1-bromo-2,5-dimethoxybenzene

diethylamine

ethyl bromide

2,5-dimethoxyaniline

Downstream raw materials:

4,4'-methylenebis(N,N-diethyl-2,5-dimethoxyaniline)