(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester
CAS No.:188743-71-7
Molecular Formula:C₃₃H₅₃N₃O₇
Molecular Weight:603.8
Hs Code.:

Synonyms:(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

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Chemical Property of (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

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Technology Process of (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

There total 9 articles about (S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 155880-02-7
(4S)-2-[2-hydroxyphenyl]-Δ²-1,3-oxazoline-4-carboxylic acid

: 945496-84-4
(S)-2-Amino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

: 188743-71-7
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/jo980063o

Reference yield:

: 157505-72-1
(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

: 188743-71-7
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / CH₂Cl₂ / 14 h / Ambient temperature

2: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

3: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o

Reference yield:

: 171287-53-9
(S)-2-Benzyloxycarbonylamino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

: 188743-71-7
(S)-6-(Hexadecanoyl-hydroxy-amino)-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10percent Pd-C / methanol / 3 h / 735.5 Torr / Ambient temperature

2: 91 percent / HOAt, EDC-HCl / dimethylformamide / 3 h / Ambient temperature

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o