1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

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Chemical Name:1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole
CAS No.:1262052-11-8
Molecular Formula:C₃₆H₄₂FNO₃
Molecular Weight:555.733
Hs Code.:

Synonyms:1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

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Chemical Property of 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

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Technology Process of 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

There total 4 articles about 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1262052-10-7
2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethylamine

: 135833-82-8
1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-hexanedione

: 1262052-11-8
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

Guidance literature:: With toluene-4-sulfonic acid; In 5,5-dimethyl-1,3-cyclohexadiene; water; for 168h; Reflux;
DOI:10.1016/j.tet.2010.10.028

Reference yield:

: 1431291-02-9
methyl 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate

: 1262052-11-8
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol; water / 48 h / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere; Reflux

3: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 168 h / Reflux; Inert atmosphere

With ammonium hydroxide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water;
DOI:10.1002/ejoc.201201154

Reference yield:

: 77-76-9
2,2-dimethoxy-propane

: 1262052-11-8
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / dichloromethane / 24 h / Reflux; Inert atmosphere

2: ammonium hydroxide / methanol; water / 48 h / Inert atmosphere

3: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere; Reflux

4: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 168 h / Reflux; Inert atmosphere

With ammonium hydroxide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; water;
DOI:10.1002/ejoc.201201154