1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

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Chemical Name:1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid
CAS No.:1262052-13-0
Molecular Formula:C₃₇H₄₂FNO₅
Molecular Weight:599.743
Hs Code.:

Synonyms:1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

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Chemical Property of 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

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Technology Process of 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

There total 6 articles about 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1262052-12-9
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-4-iodo-5-isopropyl-3-phenyl-1H-pyrrole

: 1262052-13-0
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-4-iodo-5-isopropyl-3-phenyl-1H-pyrrole; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -80 ℃; for 0.166667h;

carbon dioxide; In tetrahydrofuran; hexane; at -80 - 20 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2010.10.028

Reference yield: 81.0%

: 124-38-9,18923-20-1
carbon dioxide

: 1262052-11-8
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole

: 1262052-13-0
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole; With tert.-butyl lithium; In tetrahydrofuran; at -80 ℃; Inert atmosphere;

carbon dioxide; for 0.25h; Inert atmosphere;
DOI:10.1002/ejoc.201201154

Reference yield:

: 1431291-02-9
methyl 2-{(4S,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetate

: 1262052-13-0
1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium hydroxide / methanol; water / 48 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 °C / Inert atmosphere; Reflux

3.1: toluene-4-sulfonic acid / 5,5-dimethyl-1,3-cyclohexadiene / 168 h / Reflux; Inert atmosphere

4.1: tert.-butyl lithium / tetrahydrofuran / -80 °C / Inert atmosphere

4.2: 0.25 h / Inert atmosphere

With ammonium hydroxide; lithium aluminium tetrahydride; tert.-butyl lithium; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water;
DOI:10.1002/ejoc.201201154