trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

Base Information

Chemical Name:trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester
CAS No.:1426572-92-0
Molecular Formula:C₁₈H₂₆N₆O₃
Molecular Weight:374.443
Hs Code.:

Synonyms:trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

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Chemical Property of trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

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Technology Process of trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

There total 3 articles about trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1426572-84-0
trans-5-benzyloxyamino-2-cyano-piperidine-1-carboxylic acid-1-tert-butyl ester

: 1426572-92-0
trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

Guidance literature:: trans-5-benzyloxyamino-2-cyano-piperidine-1-carboxylic acid-1-tert-butyl ester; With sodium azide; triethylamine hydrochloride; In toluene; at 100 ℃; for 2h;

With ammonium chloride; In water; toluene; at 25 - 35 ℃; for 0.25h;

Reference yield:

: 1426573-07-0
(2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

: 1426572-92-0
trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 1.5 h

1.2: 0.67 h / -40 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C

3.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C

3.2: 0.25 h / 25 - 35 °C

With sodium azide; pivaloyl chloride; triethylamine hydrochloride; triethylamine; trifluoroacetic anhydride; In dichloromethane; toluene;

Reference yield:

: 1426572-83-9
trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

: 1426572-92-0
trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C

2.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C

2.2: 0.25 h / 25 - 35 °C

With sodium azide; triethylamine hydrochloride; triethylamine; trifluoroacetic anhydride; In dichloromethane; toluene;