trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1426572-94-2
Molecular Formula:C₁₉H₂₈N₆O₃
Molecular Weight:388.47
Hs Code.:

Synonyms:trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426572-92-0
trans-5-benzyloxyamino-2-(1H-tetrazol-5-yl)-piperidine-1-carboxylic acid-1-tert-butyl ester

: 74-88-4
methyl iodide

: 1426572-93-1
trans-5-(benzyloxyamino)-2-(1-methyl-1H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

: 1426572-94-2
trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 35 ℃; for 2h; Overall yield = 91 %; Overall yield = 5.7 g;

Reference yield:

: 1426572-83-9
trans-5-(benzyloxyamino)-2-carbamoylpiperidine-1-carboxylic acid tert-butyl ester

: 1426572-94-2
trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C

2.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C

2.2: 0.25 h / 25 - 35 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 35 °C

With sodium azide; triethylamine hydrochloride; caesium carbonate; triethylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1426573-07-0
(2S,5R)-1-[(1,1-dimethylethyl)carbonyl]-5-[(benzyloxy)amino]piperidine-2-carboxylic acid

: 1426572-94-2
trans-5-(benzyloxyamino)-2-(2-methyl-2H-tetrazol-5-yl)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride / dichloromethane / 1.5 h

1.2: 0.67 h / -40 °C

2.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 6 h / 0 - 35 °C

3.1: sodium azide; triethylamine hydrochloride / toluene / 2 h / 100 °C

3.2: 0.25 h / 25 - 35 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 35 °C

With sodium azide; pivaloyl chloride; triethylamine hydrochloride; caesium carbonate; triethylamine; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; toluene;