4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid

Base Information

• Chemical Name: 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid
• CAS No.: 1034123-68-6
• Molecular Formula: C₁₁H₁₂O₅
• Molecular Weight: 224.213
• Mol file: 1034123-68-6.mol

Synonyms:4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid

Chemical Property of 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid

There total 2 articles about 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piruvate (57-60-3) + 4-methoxy-benzaldehyde (123-11-5) → 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid (1034123-68-6)

Guidance literature:

With 4-hydroxy-2-ketoheptane-1,7-dioate aldolase from Acinetobacter baumannii; zinc(II) chloride; In aq. buffer; at 25 ℃; for 1h; pH=7; stereoselective reaction; Enzymatic reaction;

DOI:10.1016/j.jbc.2021.101280

Reference yield:

Oxalacetic acid (328-42-7) + 4-methoxy-benzaldehyde (123-11-5) → 4-hydroxy-4-(4-methoxyphenyl)-2-ketobutanoic acid (1034123-68-6) + (E)-4-(4-methoxy-phenyl)-2-oxo-3-butenoic acid (17451-21-7,128935-12-6)

Guidance literature:

4-methoxy-benzaldehyde; With macrophomate synthase from Macrophoma commelinae; magnesium chloride; In acetonitrile; at 20 ℃; for 0.166667h; pH=7.0; aq. phosphate buffer; Enzymatic reaction;

Oxalacetic acid; In acetonitrile; for 7h; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/ja8017994

upstream raw materials:

Oxalacetic acid

4-methoxy-benzaldehyde

piruvate