2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

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Chemical Name:2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine
CAS No.:1071128-36-3
Molecular Formula:C₂₃H₃₁FN₄O₃
Molecular Weight:430.523
Hs Code.:

Synonyms:2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

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Chemical Property of 2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

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Technology Process of 2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

There total 2 articles about 2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071128-30-7
2,6-difluoro-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)pyridine

: 2393-23-9
4-methoxy-benzylamine

: 1071128-36-3
2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

Guidance literature:: With triethylamine; In 1-methyl-pyrrolidin-2-one; at 170 ℃; for 2h; Microwave irradiation;

Reference yield:

: 3512-17-2
2,4,6-trifluoropyridine

: 1071128-36-3
2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 2 h / 20 °C

2: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 170 °C / Microwave irradiation

With triethylamine; In 1-methyl-pyrrolidin-2-one; ethanol;

Reference yield: 11.0%

: 1071128-36-3
2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine

: 1679-18-1
4-Chlorophenylboronic acid

: 4-[3-(methylamino)azetidin-1-yl]-6-phenylpyridin-2-amine bisacetate salt

Guidance literature:: 2-(4-methoxybenzylamino)-4-(3-(N-methyl-N-tert-butoxycarbonylamino)pyrrolidino)-6-fluoropyridine; 4-Chlorophenylboronic acid; With sodium carbonate; chloro(di-2-norbornylphosphino)-(2'-dimethylamin-1,1'-biphenyl-2-yl)palladium(II); In 1,2-dimethoxyethane; water; at 80 ℃; for 18h;

With lithium aluminium tetrahydride; In tetrahydrofuran; for 42h; Heating / reflux;