Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester
• CAS No.: 147250-13-3
• Molecular Formula: C₃₅H₄₂O₅S
• Molecular Weight: 574.781

Synonyms:Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester

Chemical Property of Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester

Chemical Property:

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Technology Process of Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester

There total 1 articles about Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether) (126559-84-0) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester (147250-13-3)

Guidance literature:

With pyridine;

DOI:10.1016/j.bmc.2004.06.017

Reference yield: 71.0%

phenylmethanethiol (100-53-8) + Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester (147250-13-3) → 3,17β-bis(benzyloxy)-11β-benzylthioethylestra-1,3,5(10)-triene (756844-19-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmc.2004.06.017

Reference yield: 60.0%

Dimethyldisulphide (624-92-0) + Methanesulfonic acid 2-((8S,9S,11R,13S,14S,17S)-3,17-bis-benzyloxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-11-yl)-ethyl ester (147250-13-3) → 3,17β-bis(benzyloxy)-11β-methylthioethylestra-1,3,5(10)-triene

Guidance literature:

With sodium; In tetrahydrofuran; N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmc.2004.06.017

upstream raw materials:

11β-(2-hydroxyethyl)estra-1,3,5(10)-triene-3,17β-diol 3,17-bis(benzyl ether)

methanesulfonyl chloride

Downstream raw materials:

3,17β-bis(benzyloxy)-11β-benzylthioethylestra-1,3,5(10)-triene

(8S,9S,11R,13S,14S,17S)-11-(2-Benzylsulfanyl-ethyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

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