4'-Methoxy-2-methyl-biphenyl

Base Information

• Chemical Name: 4'-Methoxy-2-methyl-biphenyl
• CAS No.: 92495-54-0
• Molecular Formula: C14H14 O
• Molecular Weight: 198.26
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID10438537
• Nikkaji Number: J604.151E
• Wikidata: Q82254299
• Mol file: 92495-54-0.mol

Synonyms:4'-METHOXY-2-METHYL-BIPHENYL;92495-54-0;1-methoxy-4-(2-methylphenyl)benzene;4-o-tolylanisole;4'-methoxy-2-methyl-1,1'-biphenyl;4-Methoxy-2'-methyl-1,1'-biphenyl;p-Tolyl Anisol;2-Methyl-4'-methoxy-1,1'-biphenyl;4-(o-tolyl)anisole;Anisole,p-(o-tolyl)-;2-methyl-4'-methoxybiphenyl;4-Methoxy-2'-methylbiphenyl;SCHEMBL321832;DTXSID10438537;GNYJFZNIMOMCCF-UHFFFAOYSA-N;4-METHOXY-2-METHYL-BIPHENYL;MFCD06802485;AKOS004118832;BB 0223580;E90042

Chemical Property of 4'-Methoxy-2-methyl-biphenyl

Chemical Property:

• Melting Point: 97.8-98.6℃
• Boiling Point: 140-141.5℃ (13 Torr)
• PSA: 9.23000
• LogP: 3.67060
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 198.104465066
• Heavy Atom Count: 15
• Complexity: 182

Purity/Quality:

98%Min ^*data from raw suppliers

4'-METHOXY-2-METHYL-BIPHENYL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=CC=C1C2=CC=C(C=C2)OC

Technology Process of 4'-Methoxy-2-methyl-biphenyl

There total 18 articles about 4'-Methoxy-2-methyl-biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ortho-tolylmagnesium bromide (932-31-0) + 1-fluoro-4-methoxybenzene (459-60-9) → 2,2'-dimethyl-1,1'-biphenyl (605-39-0) + 4'-methoxy-2-methylbiphenyl (92495-54-0)

Guidance literature:

With C₆₈H₇₂Cl₂N₆NiP₂; In diethyl ether; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201001022

Reference yield: 90.0%

ortho-tolylmagnesium bromide (932-31-0) + 4-chloromethoxybenzene (623-12-1) → 2,2'-dimethyl-1,1'-biphenyl (605-39-0) + 4'-methoxy-2-methylbiphenyl (92495-54-0)

Guidance literature:

With C₆₈H₇₂Cl₂N₆NiP₂; In diethyl ether; at 25 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201001022

Reference yield: 69.0%

carbon monoxide (201230-82-2) + 2-Methylphenylboronic acid (16419-60-6) + 4-methoxybenzenediazonium tetrafluoroborate (459-64-3) → (4-methoxyphenyl)(2-methylphenyl)methanone (41204-59-5) + 4'-methoxy-2-methylbiphenyl (92495-54-0)

Guidance literature:

With palladium diacetate; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 1,4-dioxane; at 100 ℃; for 5h; under 760 Torr;

DOI:10.1016/S0040-4039(02)02186-X

upstream raw materials:

p-methoxyphenyllithium

(2-methylphenyl)lithium

carbon monoxide

2-Methylphenylboronic acid

Downstream raw materials:

1-Methyl-2-(1,4,4-trimethoxy-cyclohexa-2,5-dienyl)-benzene

4'-Methoxy-2-((Z)-styryl)-biphenyl

4'-Methoxy-2-((E)-styryl)-biphenyl

4'-methoxybiphenyl-2-carboxylic acid