ETHOXYCARBONYLMETHYL PHENYLACETATE

Base Information

• Chemical Name: ETHOXYCARBONYLMETHYL PHENYLACETATE
• CAS No.: 91497-39-1
• Molecular Formula: C12H14 O4
• Molecular Weight: 222.241
• Hs Code.: 2916399090
• Mol file: 91497-39-1.mol

Synonyms:Glycolicacid, ethyl ester, phenylacetate (6CI,7CI)

Chemical Property of ETHOXYCARBONYLMETHYL PHENYLACETATE

Chemical Property:

• Vapor Pressure: 0.00041mmHg at 25°C
• Refractive Index: n20/D 1.497(lit.)
• Boiling Point: 316.5°C at 760 mmHg
• Flash Point: >230 °F
• PSA: 52.60000
• Density: 1.121 g/mL at 25 °C(lit.)
• LogP: 1.33540

Purity/Quality:

97% ^*data from raw suppliers

2-Ethoxy-2-oxoethyl2-phenylacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHOXYCARBONYLMETHYL PHENYLACETATE

There total 8 articles about ETHOXYCARBONYLMETHYL PHENYLACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

phenylacetic acid (103-82-2) + ethyl bromoacetate (105-36-2) → 2-ethoxy-2-oxoethyl 2-phenylacetate (91497-39-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; Heating;

DOI:10.1016/j.bmc.2005.04.055

Reference yield: 80.0%

diazoacetic acid ethyl ester (623-73-4) + phenylacetic acid (103-82-2) → 2-ethoxy-2-oxoethyl 2-phenylacetate (91497-39-1)

Guidance literature:

In hexafluoropropan-2-ol; at 20 ℃; for 4h; chemoselective reaction;

DOI:10.1021/ol102923h

Reference yield:

phenylacetic acid (103-82-2) + chloroacetic acid ethyl ester (105-39-5) → 2-ethoxy-2-oxoethyl 2-phenylacetate (91497-39-1)

Guidance literature:

With triethylamine; In tetrahydrofuran; Reflux;

DOI:10.1016/j.bmcl.2012.11.090

upstream raw materials:

ethyl 2-hydroxyacetate

phenylacetyl chloride

phenylacetic acid

ethyl bromoacetate

Downstream raw materials:

O--glykolsaeure

C₁₈H₁₆O₄

4-methoxy-3-phenyl-5-(phenylmethylene)furan-2(5H)-one

(Z)-5-benzylidene-4-hydroxy-3-phenylfuran-2(5H)-one