2,3-Bis(p-methoxyphenyl)acrylonitrile

Base Information

• Chemical Name: 2,3-Bis(p-methoxyphenyl)acrylonitrile
• CAS No.: 63785-34-2
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.312
• NSC Number: 23416
• UNII: 29D9UWI50A
• Nikkaji Number: J800.721G,J3.129.266B
• Wikidata: Q27115921
• ChEMBL ID: CHEMBL82022
• Mol file: 63785-34-2.mol

Synonyms:6443-74-9;2,3-Bis(p-methoxyphenyl)acrylonitrile;2,3-Bis(4-methoxyphenyl)acrylonitrile;(Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile;NSC23416;CHEMBL82022;29D9UWI50A;CHEBI:34226;(2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile;2,3-bis(4-methoxyphenyl)prop-2-enenitrile;2,3-Di(4-methoxyphenyl)acrylonitrile, (Z)-;Benzeneacetonitrile,4-methoxy-a-[(4-methoxyphenyl)methylene]-;MLS002638941;UNII-29D9UWI50A;SCHEMBL6801712;SCHEMBL6801718;HMS1529P01;BDBM50145703;NSC-23416;STL433577;2,3-Di(4-methoxyphenyl)acrylonitrile;AKOS022022521;(Z)-alpha-Cyano-4,4'-dimethoxystilbene;NCGC00176158-01;(Z)-2,3-di(4-methoxyphenyl)acrylonitrile;(Z)-2,3-Bis(4-methoxyphenyl)acrylonitrile;(2z)-2,3-bis(4-methoxyphenyl)acrylonitrile;(Z)-2,3-Bis-(4-methoxy-phenyl)-acrylonitrile;(Z)-.ALPHA.-CYANO-4,4'-DIMETHOXYSTILBENE;(Z)-1,2-bis(4-methoxyphenyl)-1-ethenyl cyanide;Q27115921;BENZENEACETONITRILE, 4-METHOXY-.ALPHA.-((4-METHOXYPHENYL)METHYLENE)-, (.ALPHA.Z)-;Benzeneacetonitrile, 4-methoxy-alpha-((4-methoxyphenyl)methylene)-, (alphaZ)-;63785-34-2

Chemical Property of 2,3-Bis(p-methoxyphenyl)acrylonitrile

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 265.110278721
• Heavy Atom Count: 20
• Complexity: 366

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=C(C#N)C2=CC=C(C=C2)OC
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C(\C#N)/C2=CC=C(C=C2)OC

Technology Process of 2,3-Bis(p-methoxyphenyl)acrylonitrile

There total 10 articles about 2,3-Bis(p-methoxyphenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-methoxy-benzaldehyde (123-11-5) + p-methoxybenzylnitrile (104-47-2) → (2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile (63785-34-2)

Guidance literature:

With sodium methylate; In ethanol; at 20 ℃; for 2h;

DOI:10.3184/030823409X460687

Reference yield: 50.0%

p-methoxybenzylnitrile (104-47-2) → (2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile (63785-34-2)

Guidance literature:

With sodium amide; In toluene; for 6h; Reflux;

DOI:10.3184/030823409X460687

Reference yield: 20.0%

(Z)-3-(4-methoxyphenyl)-2-phenylacrylonitrile (5432-07-5) → (Z)-2,3-diphenylacrylonitrile (6114-57-4) + (2Z)-2,3-bis(4-methoxyphenyl)prop-2-enenitrile (63785-34-2) + (Z)-2-(4-methoxyphenyl)-3-phenylpropenenitrile (54648-50-9) + (E)-2-phenyl-3-(4-methoxyphenyl)acrylonitrile (52565-62-5)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; at 130 ℃; for 0.166667h; microwave irradiation;

DOI:10.1039/b418156e

upstream raw materials:

4-methoxy-benzaldehyde

p-methoxybenzylnitrile

(4-Dimethylamino-phenylsulfanyl)-(4-methoxy-phenyl)-acetonitrile

(Z)-3-(4-methoxyphenyl)-2-phenylacrylonitrile

Downstream raw materials:

(Z)-2,3-bis(4-methoxyphenyl)acrylaldehyde

4,5-bis(4-methoxyphenyl)penta-(2E,4Z)-dienoyl azide

4,5-bis(4-methoxyphenyl)penta-(2E,4Z)-dienoic acid

(Z)-2,3-Bis-(4-methoxy-phenyl)-acrylic acid methyl ester