Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

Base Information

Chemical Name:Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate
CAS No.:1204423-89-1
Molecular Formula:C₁₄H₁₄BrNO₄
Molecular Weight:340.173
Hs Code.:

Synonyms:Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

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Chemical Property of Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

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Technology Process of Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

There total 10 articles about Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1204423-85-7
Methyl 3-[3-(4-methoxyphenyl)isoxazol-5-yl]propionate

: 1204423-89-1
Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

Guidance literature:: Methyl 3-[3-(4-methoxyphenyl)isoxazol-5-yl]propionate; With N-Bromosuccinimide; acetic acid; at 70 ℃; for 4h;

With water; sodium hydroxide;

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1204423-89-1
Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 1 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

3.1: triethylamine / dichloromethane / 2 h / 20 °C

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

5.1: potassium carbonate / acetonitrile / 20 °C

6.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

6.2: 6.5 h / 120 °C

7.1: tetrahydrofuran; methanol / 48 h / 20 °C

8.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 1204423-89-1
Methyl 3-[4-bromo-3-(4-methoxyphenyl)isoxazol-5-yl]propionate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 2.5 h / 20 °C / Cooling with ice

2.1: triethylamine / dichloromethane / 2 h / 20 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / Cooling with ice

4.1: potassium carbonate / acetonitrile / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 72 h / 20 °C

5.2: 6.5 h / 120 °C

6.1: tetrahydrofuran; methanol / 48 h / 20 °C

7.1: N-Bromosuccinimide; acetic acid / 4 h / 70 °C

With N-chloro-succinimide; N-Bromosuccinimide; carbon tetrabromide; water; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;